High rate of subsequent cancers in MCC

Our study does confirm that patients with MCC are at higher risk for developing other cancers,” study author Lisa C. Zaba, MD, PhD, associate professor of dermatology and director of the Merkel cell carcinoma multidisciplinary clinic, Stanford (Calif.) Cancer Center, said in an interview. “MCC is a highly malignant cancer with a 40% recurrence risk.

COVID Vaccine and Psoriasis

Single-stranded mRNA molecules, like those contained in the Pfizer and Moderna COVID-19 vaccines, are activators of innate immune cells. Binding of mRNA to innate immune cells produces a potent type I interferon (IFN) response that is thought to play a central role in inflammation in some patients with autoimmune disorders. [Specifically,] type I IFN is thought to play a role in the initiation phase of psoriasis when people first develop the disease, although chronic psoriasis is perpetuated by overactivation of a different pathway, the Th17 adaptive immune response.